Iain Rennie Hospice at Home is staging its annual eight-mile walk in the area next month and will be hoping to improve on last year's £120,000 fundraising total.
However, organisers want to try something different this year - to get more than 1,000 people wearing fancy dress costumes and doing a conga.
If they are successful, they could break a world record in the process, as well as fill the charity's coffers considerably.
Martin Phillips, the mayor of Amersham, told the Bucks Free Press: "I hope we can all come together to set a new world record, have fun and raise money at the same time."
Helen Mariner, spokeswoman for Iain Rennie Hospice at Home, added that she is confident local people will "rise to the challenge".
Running the hospice's services costs £3.5 million, but primary care trusts contribute only 12 per cent of this sum.
As a result, it is very reliant on donations from the public.
One appropriate fancy dress costume may be a Batman outfit, while a Superman costume could suit the occasion as well.